Cell Specific eQTL Analysis without Sorting Cells
نویسندگان
چکیده
منابع مشابه
Cell Specific eQTL Analysis without Sorting Cells
The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not always be available. We performed a genome-environment interaction (GxE) meta-analysis on data from 5,683 samples to infer the cell type specific...
متن کاملMatrix eQTL: ultra fast eQTL analysis via large matrix operations
MOTIVATION Expression quantitative trait loci (eQTL) analysis links variations in gene expression levels to genotypes. For modern datasets, eQTL analysis is a computationally intensive task as it involves testing for association of billions of transcript-SNP (single-nucleotide polymorphism) pair. The heavy computational burden makes eQTL analysis less popular and sometimes forces analysts to re...
متن کاملCell Specific Analysis of Arabidopsis Leaves Using Fluorescence Activated Cell Sorting
After initiation of the leaf primordium, biomass accumulation is controlled mainly by cell proliferation and expansion in the leaves(1). However, the Arabidopsis leaf is a complex organ made up of many different cell types and several structures. At the same time, the growing leaf contains cells at different stages of development, with the cells furthest from the petiole being the first to stop...
متن کاملeQTL Analysis by Linear Model
This vignette describes eQTL mapping, visualization and other analysis tools in R/eMap package. To improve efficiency, we implemented the computational intensive parts of our algorithms by C using GSL library (http://www.gnu.org/software/gsl/). Therefore in order to install this R package, GSL library need to be installed. Users may need to change the Makevars file in src folder to provide the ...
متن کاملSpecific sorting of single bacterial cells with microfabricated fluorescence-activated cell sorting and tyramide signal amplification fluorescence in situ hybridization.
When attempting to probe the genetic makeup of diverse bacterial communities that elude cell culturing, researchers face two primary challenges: isolation of rare bacteria from microbial samples and removal of contaminating cell-free DNA. We report a compact, low-cost, and high-performance microfabricated fluorescence-activated cell sorting (μFACS) technology in combination with a tyramide sign...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2015
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1005223